Chronic kidney disease (CKD) and acute kidney injury (AKI) have increased dramatically. Patients often struggle with fatigue, electrolyte disturbances, cardiovascular complications and increased mortality. But there is more: the kidneys are in constant dialogue with the intestines. The gut-kidney axis determines how urea, toxins and immune activation proceed.

Multi-omics makes this invisible communication visible and can help physicians better understand and preventively manage CKD and AKI.

The clinical problem

• In CKD, urea and toxins rise, leading to fatigue, vascular damage and immune dysfunction.
• Intestinal dysbiosis exacerbates this process by toxin-producing bacteria (e.g., indoxyl sulfate, p-cresol).
• In AKI, we see that intestinal barrier loss provokes systemic inflammation.(Ali et al., Int Urol Nephrol 2024).
• Patients with IgA nephropathy or lupus nephritis show specific intestinal renal crosstalk profiles.(Wang et al., Theranostics 2025).

Multi-omics insights into the gut-kidney axis

1. Hyperuricemia & Akkermansia
   - Fu et al., ASM 2025: showed that Akkermansia muciniphila (live or inactivated) lowers uric acid via intestinal renal crosstalk and can mitigate hyperuricemia.
2. IgA nephropathy
   - Wang et al., 2025: multi-omics shows that specific microbial profiles co-drive IgA aggregation and renal inflammation.
3. Sepsis & organ crosstalk
   - Borges et al, Ann Intens Care 2024: In sepsis, gut-kidney-lung crosstalk is disrupted, exacerbating systemic damage.
4. CKD progression
   - Giordano, UU 2025: in vitro multi-omics platform reveals how microbiota-derived metabolites accelerate or inhibit CKD progression.
5. Inflammatory crosstalk
   - Herranz, EMBO J 2025: described how gut-kidney interactions increase tumor mortality through NF-κB activation.

Innovative solutions for the clinic

1. Renal Detox Index
   - My InnerSelfie analyzes microbial toxins (indoxyl sulfate, p-cresol) and correlation with DNA variants in detox pathways.
2. Microbiome-Uremic Toxin Map
   - Visualizes which bacteria amplify or buffer toxins.
3. Immune Crosstalk Scan
   - Detects gut-driven inflammatory pathways that exacerbate CKD or AKI.
4. Therapy personalization
   - Supports nephrologists in matching dialysis, nutrition and medication to the microbiome profile.

Why My InnerSelfie is unique

• Multi-omics integration: DNA, metabolites and microbiome in a single clinical profile.
• Crosstalk focus: we map the dialogue between gut and kidneys.
• Preventive precision: risks of progression of CKD or AKI become apparent early.
• Additional tool for the physician: decisions always remain in the hands of the nephrologist; we provide additional insights.
• Tomorrow's care: innovative, preventive and always customized. Innovation of today becomes the standard of tomorrow - safe and scientifically based.

Key insights

• Intestinal renal crosstalk plays a crucial role in CKD, AKI and IgA nephropathy.
• Dysbiosis amplifies toxin production and inflammation; multi-omics makes this visible.
• My InnerSelfie offers nephrologists new tools to monitor disease progression and personalize therapy.

Scientific references

• Fu Y, Chen J, Cao Q, et al. Gut-kidney axis modulation by Akkermansia muciniphila mitigates hyperuricemia. ASM J. 2025.
• Wang X, Zhou XJ, Qiao X, et al. Systemic mechanisms in IgA nephropathy: gut-kidney crosstalk. Theranostics. 2025.
• Borges A, Bento L. Organ crosstalk and dysfunction in sepsis. Ann Intens Care. 2024.
• Herranz H. Inflammatory crosstalk: gut-kidney interplay in tumor host mortality. EMBO J. 2025.
• Giordano L. Gut-kidney axis in CKD: in vitro insights into interorgan crosstalk. UU Research Portal. 2025.
• Ali A, Wu L, Ali SS. Gut microbiota and acute kidney injury: immunological crosstalk. Int Urol Nephrol. 2024.